Role of HSD17B13 in the liver physiology and pathophysiology

Wen Su; Zhuo Mao; Yiao Liu; Xiaoyan Zhang; Weizhen Zhang; Jan-Ake Gustafsson; Youfei Guan

doi:10.1016/j.mce.2018.10.014

Role of HSD17B13 in the liver physiology and pathophysiology

Mol Cell Endocrinol. 2019 Jun 1:489:119-125. doi: 10.1016/j.mce.2018.10.014. Epub 2018 Oct 24.

Authors

Wen Su¹, Zhuo Mao², Yiao Liu², Xiaoyan Zhang³, Weizhen Zhang², Jan-Ake Gustafsson⁴, Youfei Guan⁵

Affiliations

¹ Shenzhen University Medical Center, Shenzhen University Health Science Center, Shenzhen, China; Department of Pathology, Shenzhen University Health Science Center, Shenzhen, China.
² Shenzhen University Medical Center, Shenzhen University Health Science Center, Shenzhen, China.
³ Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, 116044, China; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, 116044, China.
⁴ Center for Nuclear Receptors and Cell Signaling, University of Houston, 3013 Cullen Blv, 77204, Houston, TX, USA; Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden. Electronic address: jgustafs@central.uh.edu.
⁵ Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, Liaoning, 116044, China; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, 116044, China. Electronic address: youfeiguan@szu.edu.cn.

PMID: 30365983
DOI: 10.1016/j.mce.2018.10.014

Abstract

17β-Hydroxysteroid dehydrogenases (HSD17Bs) comprise a large family of 15 members that are mainly involved in sex hormone metabolism. Some HSD17Bs enzymes also play key roles in cholesterol and fatty acid metabolism. Recent study showed that hydroxysteroid 17β-dehydrogenase 13 (HSD17B13), an enzyme with unknown biological function, is a novel liver-specific lipid droplet (LD)-associated protein in mouse and humans. HSD17B13 expression is markedly upregulated in patients and mice with non-alcoholic fatty liver disease (NAFLD). Hepatic overexpression of HSD17B13 promotes lipid accumulation in the liver. In this review, we summarize recent progress regarding the role of HSD17B13 in the regulation of hepatic lipid homeostasis and discuss genetic, genomic and proteomic evidence supporting the pathogenic role of HSD17B13 in NAFLD. We also emphasize its potential as a biomarker of advanced liver disease, such as non-alcoholic steatohepatitis (NASH) and liver cancer.

Keywords: Genome-wide association study; HSD17B13; Lipid droplets; NAFLD; Proteomics.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

17-Hydroxysteroid Dehydrogenases / chemistry
17-Hydroxysteroid Dehydrogenases / metabolism*
Animals
Humans
Liver / enzymology*
Liver / physiopathology*
Liver Diseases / enzymology
Models, Biological

Substances

17-Hydroxysteroid Dehydrogenases
3 (or 17)-beta-hydroxysteroid dehydrogenase